<i>In vivo</i> nanoparticle-based T cell imaging can predict therapy response towards adoptive T cell therapy in experimental glioma
Jessica Hunger, Katharina Schregel, Berin Boztepe, Dennis A. Agardy, Verena Turco, Kianush Karimian‐Jazi, Ina Weidenfeld, Yannik Streibel, Manuel Fischer, Volker Sturm, Rachel Santarella‐Mellwig, Michael Kilian, Kristine Jähne, Katharina Sahm, Wolfgang Wick, Lukas Bunse, Sabine Heiland, Theresa Bunse, Martin Bendszus, Michael Platten, Michael O. Breckwoldt
Abstract
This study showcases a rational for monitoring adoptive T cell therapies non-invasively by iron oxide NP in gliomas to track intratumoral T cell influx and ultimately predict treatment outcome.
Topics & Concepts
Adoptive cell transferT cellGliomaImmunotherapyCytotoxic T cellChimeric antigen receptorCell therapyCancer researchT-cell receptorTumor microenvironmentEx vivoFlow cytometryChemistryBiologyIn vivoImmunologyCell biologyImmune systemIn vitroStem cellBiochemistryBiotechnologyCAR-T cell therapy researchAdvanced Electron Microscopy Techniques and ApplicationsSingle-cell and spatial transcriptomics