Enterobactin- and salmochelin-β-lactam conjugates induce cell morphologies consistent with inhibition of penicillin-binding proteins in uropathogenic <i>Escherichia coli</i> CFT073
Artur Sargun, Timothy C. Johnstone, Hui Zhi, Manuela Raffatellu, Elizabeth M. Nolan
Abstract
Siderophore-β-lactam conjugates based on enterobactin and diglucosylated enterobactin enter the periplasm of uropathogenic <italic>E. coli</italic> CFT073 <italic>via</italic> the FepA and IroN transporters, and target penicillin-binding proteins.
Topics & Concepts
EnterobactinEscherichia coliConjugateChemistryPenicillinMicrobiologyLactamPenicillin binding proteinsCombinatorial chemistryStereochemistryBiochemistryAntibioticsBiologyGeneMathematical analysisMathematicsEscherichia coli research studiesAntibiotic Resistance in BacteriaUrinary Tract Infections Management