Radial wall strain: a novel angiographic measure of plaque composition and vulnerability
Huihong Hong, Chunming Li, Juan Luis Gutiérrez‐Chico, Zhiqing Wang, Jiayue Huang, Miao Chu, Takashi Kubo, Lianglong Chen, William Wijns, Shengxian Tu
Abstract
BACKGROUND: The lipid-to-cap ratio (LCR) and thin-cap fibroatheroma (TCFA) derived from optical coherence tomography (OCT) are indicative of plaque vulnerability. AIMS: We aimed to explore the association of a novel method to estimate radial wall strain (RWS) from angiography with plaque composition and features of vulnerability assessed by OCT. METHODS: was computed as the maximum deformation of lumen diameter throughout the cardiac cycle, expressed as a percentage of the largest lumen diameter. The LCR and TCFA were automatically determined on OCT images by a recently validated algorithm based on artificial intelligence. RESULTS: ≤12%. CONCLUSIONS: Angiography-derived RWS was significantly correlated with plaque composition and known OCT features of plaque vulnerability in patients with intermediate coronary stenosis.