Structural basis for the inhibition of the SARS-CoV-2 main protease by the anti-HCV drug narlaprevir
Yu Bai, Fei Ye, Yong Feng, Hanyi Liao, Hao Song, Jianxun Qi, George F. Gao, Wenjie Tan, Lifeng Fu, Yi Shi
Topics & Concepts
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Sars virusVirologyProtease2019-20 coronavirus outbreakCoronavirus disease 2019 (COVID-19)DrugProtease inhibitor (pharmacology)MedicinePharmacologyImmunologyBiologyEnzymeViral loadVirusPathologyBiochemistryInfectious disease (medical specialty)Antiretroviral therapyOutbreakDiseaseComputational Drug Discovery MethodsPharmacological Effects of Natural CompoundsSynthesis and biological activity