Thiosemicarbazone derivatives of transition metals as multi-target drugs: A review
Sakshi Gupta, Nidhi Singh, Tahmeena Khan, Seema Joshi
Abstract
The mutations of bacteria and viruses along with the resistance of various targets to the existing drugs have emerged as great challenges in the medical field. This imposes the need for novel drugs and medicines to resolve such threats. Metal complexes with thiosemicarbazone (TSC) and their derivatives have been reported to show good medicinal values and appear to be beneficial in terms of producing less toxic and more effective drugs. Literature shows that the metals have selectivity for the target cells and their coordination influences the binding of the ligand with proteins and enzymes. The present article gives an insight into the importance of coordination of TSC with transition and inner transition metals. It also correlates the variation in the biological activities with the nature of metal bound to the TSC and the presence of substituents attached to the TSC. Various explored derivatives of biologically active TSC – metal complexes have been reviewed. This paper establishes enhancement in the biological activity of different classes of metal- TSC derivative complexes compared to their precursors. We have tried to give details of the synergic effect of metal TSC complexes and propose their future use as combination drugs.