Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling
Riccardo Rubbiani, Wenyu Wu, Anu Naik, Michele Larocca, Lukas Schneider, Roxane Padrutt, V. V. Suresh Babu, Christiane König, Doris Hinger, Caroline Maake, Stefano Ferrari, Gilles Gasser, Bernhard Spingler
Abstract
Novel tetraplatinated metalloporphyrin-based photosensitizers (PSs) are reported, which show excellent phototoxic indexes (PIs) up to 5800 against HeLa cells, which is, to the best of our knowledge, the highest value reported for any porphyrin so far. Furthermore, 67Zn isotope labelling allowed the determination of the ratio of zinc to platinum inside the cells using ICP-MS.
Topics & Concepts
PhototoxicityLabellingChemistryIsotopeEnvironmental chemistryPhotochemistryRadiochemistryBiochemistryIn vitroQuantum mechanicsPhysicsPhotodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsPorphyrin and Phthalocyanine Chemistry