SPARC knockdown attenuated TGF-β1-induced fibrotic effects through Smad2/3 pathways in human pterygium fibroblasts
Jianwu Fan, Xin Zhang, Yaping Jiang, Li Chen, Minjie Sheng, Yihui Chen
Topics & Concepts
Gene knockdownOsteonectinFibronectinChemistryCell migrationExtracellular matrixTransforming growth factorMatrix metalloproteinaseDownregulation and upregulationSMADCell biologyMMP2Molecular biologyCell growthCancer researchMatricellular proteinGene silencingApoptosisCellBiologyBiochemistryAlkaline phosphataseEnzymeGeneOsteocalcinBone and Dental Protein StudiesCorneal Surgery and TreatmentsProteoglycans and glycosaminoglycans research