The Epidermal Growth Factor Receptor Is a Relevant Host Factor in the Early Stages of The Zika Virus Life Cycle<i>In Vitro</i>
Catarina Sabino, Daniela Bender, Marie‐Luise Herrlein, Eberhard Hildt
Abstract
These data deepen the knowledge about the ZIKV infection process and demonstrate the relevance of EGFR for ZIKV entry. In light of the fact that a variety of specific and efficient inhibitors of EGFR and of EGFR-dependent signaling have been developed and licensed, repurposing of these substances could be a helpful tool to prevent the spreading of ZIKV infection in an epidemic outbreak.
Topics & Concepts
BiologyZika virusMAPK/ERK pathwayVirologyInternalizationEpidermal growth factor receptorEndosomeViral life cycleSignal transductionViral replicationFlavivirusViral entryEpidermal growth factorCancer researchCell biologyVirusReceptorGeneticsIntracellularMosquito-borne diseases and controlViral Infections and VectorsVirology and Viral Diseases