Role of kynurenine in promoting the generation of exhausted CD8<sup>+</sup> T cells in colorectal cancer.
Dandan Wu, Yufeng Zhu
Abstract
T cells through combined targeting of the IDO1/Kyn and PD-1/PD-L1 pathways in patients with CRC.
Topics & Concepts
Gene knockdownCancer researchCD8Cytotoxic T cellDownregulation and upregulationIndoleamine 2,3-dioxygenaseImmunotherapyT cellImmune systemKynurenineTumor microenvironmentChemistryBiologyMedicineImmunologyCell cultureIn vitroBiochemistryGeneGeneticsAmino acidTryptophanTryptophan and brain disordersCancer Immunotherapy and BiomarkersCancer, Stress, Anesthesia, and Immune Response