Matrinium-based active pharmaceutical ingredient ionic liquids: chain length effect on micellization, bioactivity and thermodynamic behaviors
Zhenning Yan, Mengmeng Xu, Huanhuan Lu
Abstract
) were determined. The results demonstrated their potent antibacterial efficacy. Through cytotoxicity assays, it was observed that compared to Mat, the synthesized API-ILs exhibited enhanced cytotoxic effects on two human tumor cell lines (A549 and HepG2). Furthermore, we systematically correlated anion alkyl chain length with some of the physicochemical properties and biological activities of ionic liquids to elucidate structure-property relationships.
Topics & Concepts
Active ingredientIngredientChemistryIonic liquidIonic bondingChemical engineeringThermodynamicsOrganic chemistryIonPharmacologyFood sciencePhysicsCatalysisEngineeringMedicineSurfactants and Colloidal SystemsIonic liquids properties and applicationsChemical and Physical Properties in Aqueous Solutions