Research Progress of Dendritic Cell Surface Receptors and Targeting
Chunyu Tong, Yimin Liang, Xianle Han, Zhelin Zhang, Xiaohui Zheng, Sen Wang, Bocui Song
Abstract
Dendritic cells are the only antigen-presenting cells capable of activating naive T cells in humans and mammals and are the most effective antigen-presenting cells. With deepening research, it has been found that dendritic cells have many subsets, and the surface receptors of each subset are different. Specific receptors targeting different subsets of DCs will cause different immune responses. At present, DC-targeted research plays an important role in the treatment and prevention of dozens of related diseases in the clinic. This article focuses on the current status of DC surface receptors and targeted applications.
Topics & Concepts
ReceptorDendritic cellImmune systemAntigen-presenting cellAntigenCell biologyBiologyImmunologyT cellBiochemistryImmunotherapy and Immune ResponsesImmune Cell Function and InteractionT-cell and B-cell Immunology