A photo and tumor microenvironment activated nano-enzyme with enhanced ROS generation and hypoxia relief for efficient cancer therapy
Yali Chen, Yujun Cai, Xingsu Yu, Hong Xiao, Haozhe He, Zecong Xiao, Yong Wang, Xintao Shuai
Abstract
decomposition at the tumor location can also generate a cytotoxic hydroxyl radical (˙OH), achieving an excellent chemodynamic therapy (CDT) to enhance the ROS mediated anti-cancer effect. Notably, the nano-enzyme exerts a high loading content of the photosensitizer, which minimizes the side effects probably caused by the vector.
Topics & Concepts
Photodynamic therapyReactive oxygen speciesTumor microenvironmentHypoxia (environmental)Cancer therapyCancer researchTumor hypoxiaCancerEnzymeMaterials scienceMedicineOxygenChemistryTumor cellsBiochemistryInternal medicineRadiation therapyOrganic chemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesAdvanced Nanomaterials in Catalysis