Evaluation of Phenotypic Tests to Detect Extended-Spectrum β-Lactamase (ESBL)-Producing Klebsiella oxytoca Complex Strains
Edgar I. Campos-Madueno, Aline I. Moser, Peter M. Keller, Vincent Perreten, Laurent Poirel, Patrice Nordmann, Andrea Endimiani
Abstract
Klebsiella oxytoca complex ( Ko C) species may overproduce their chromosomal class A OXY β-lactamases, conferring reduced susceptibility to piperacillin-tazobactam, expanded-spectrum cephalosporins and aztreonam. Moreover, since clavulanate maintains its ability to inhibit these enzymes, the resulting resistance phenotype may falsely resemble the production of acquired extended-spectrum β-lactamases (ESBLs).
Topics & Concepts
CeftazidimeCefepimePiperacillinBroth microdilutionMicrobiologyTazobactamCefotaximeKlebsiella oxytocaCephalosporinKlebsiella pneumoniaeBiologyAztreonamMinimum inhibitory concentrationAntibiotic resistanceAntimicrobialAntibioticsImipenemEscherichia coliBacteriaPseudomonas aeruginosaGeneticsGeneAntibiotic Resistance in BacteriaMycobacterium research and diagnosisPharmaceutical and Antibiotic Environmental Impacts