Rationale for the Role of Heparin and Related GAG Antithrombotics in COVID-19 Infection
Harry N. Magnani
Abstract
The SARS-CoV-2 pandemic has focused attention on prevention, restriction and treatment methods that are acceptable worldwide. This means that they should be simple and inexpensive. This review examines the possible role of glycosaminoglycan (GAG) antithrombotics in the treatment of COVID-19. The pathophysiology of this disease reveals a complex interplay between the hemostatic and immune systems that can be readily disrupted by SARS-CoV-2. Some of the GAG antithrombotics also possess immune-modulatory actions and since they are relatively inexpensive they could play an important role in the management of COVID-19 and its complications.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)HeparinPandemic2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Immune systemMedicineIntensive care medicineDiseaseImmunologyVirologyInfectious disease (medical specialty)Internal medicineOutbreakCOVID-19 Clinical Research StudiesVenous Thromboembolism Diagnosis and ManagementDermatological and COVID-19 studies