[1,2,4]Triazolo[4,3-c]quinazoline and bis([1,2,4]triazolo)[4,3-a:4′,3′-c]quinazoline derived DNA intercalators: Design, synthesis, in silico ADMET profile, molecular docking and anti-proliferative evaluation studies
Khaled El‐Adl, Mohamed‐Kamal Ibrahim, Mohamed S. Alesawy, Ibrahim H. Eissa
Topics & Concepts
ChemistryQuinazolineIntercalation (chemistry)StereochemistryMolecular modelIC50Docking (animal)DNAIn silicoCombinatorial chemistryDoxorubicinIn vitroBiochemistryOrganic chemistryChemotherapyGeneNursingMedicineSurgeryCancer therapeutics and mechanismsSynthesis and Biological EvaluationSynthesis and Characterization of Heterocyclic Compounds