Visible-Light-Induced Difluoroalkylated Cyclization of Novel Functionalized Aromatic Isocyanides
Yingke Feng, He Wang, Mengxing Cui, Ran Sun, Xin Wang, Chen Yang, Lei Li
Abstract
In this study, a visible-light photoredox-catalyzed difluoroalkylation of newly designed functionalized aromatic isocyanides with commercially available CF2 precursors was reported.A series of CF2-containing indole-1,2-fused diazepanones were constructed in cascade reaction through a sequence of radical addition/cyclization processes under mild conditions.This reaction not only generated a class of polycyclic indole fused seven-membered nitrogen heterocycles but also expanded the reactions of functionalized isocyanides.
Topics & Concepts
ChemistryCombinatorial chemistryPhotochemistryStereochemistryFluorine in Organic ChemistryRadical Photochemical ReactionsOxidative Organic Chemistry Reactions