Increased KIF11/kinesin-5 expression offsets Alzheimer Aβ-mediated toxicity and cognitive dysfunction
Esteban Lucero, Ronald K. Freund, Alexandra N. Smith, Noah R. Johnson, Breanna Dooling, Emily Sullivan, Olga Prikhodko, Md. Mahiuddin Ahmed, David A. Bennett, Timothy J. Hohman, Mark L. Dell’Acqua, Heidi J. Chial, Huntington Potter
Abstract
expression in neuritic plaque-positive AD patients' brains was associated with better cognitive performance and higher expression of synaptic protein mRNAs. Taken together, these mechanistic biochemical, cell biological, electrophysiological, animal model, and human data identify KIF11 as a key target of Aβ-mediated toxicity in AD, which damages synaptic structures and functions critical for learning and memory in AD.
Topics & Concepts
NeuroscienceLong-term potentiationKinesinDendritic spineMorris water navigation taskBiologyAlzheimer's diseaseHippocampal formationCell biologyChemistryMicrotubuleReceptorMedicineInternal medicineDiseaseBiochemistryAlzheimer's disease research and treatmentsMicrotubule and mitosis dynamicsMitochondrial Function and Pathology