A Multiphase Multiobjective Dynamic Genome-Scale Model Shows Different Redox Balancing among Yeast Species of the <i>Saccharomyces</i> Genus in Fermentation
David Henriques, Romain Minebois, Sebastián N. Mendoza, Laura G. Macías, Roberto Pérez‐Torrado, Eladio Barrio, Bas Teusink, Amparo Querol, Eva Balsa‐Canto
Abstract
species might use the γ-aminobutyric acid (GABA) shunt and the production of reducing equivalents as alternative routes to achieve redox balance, a novel biological insight worth being explored further. The proposed model (along with the provided code) can be applied to a wide range of batch processes started with different yeast species and media, offering a systematic and rational approach to prospect nonconventional yeast species metabolism and engineering novel cell factories.
Topics & Concepts
YeastSaccharomyces cerevisiaeFlux balance analysisBiologyComputational biologySaccharomycesFermentationMetabolic engineeringBiochemical engineeringSynthetic biologyBiochemistryGeneEngineeringMicrobial Metabolic Engineering and BioproductionFungal and yeast genetics researchFermentation and Sensory Analysis