Targeted co-delivery of a photosensitizer and an antisense oligonucleotide based on an activatable hyaluronic acid nanosystem with endogenous oxygen generation for enhanced photodynamic therapy of hypoxic tumors
Yanni Wu, Lei Ding, Zheng Cheng, Hongsheng Li, Ming Wu, Yupeng Sun, Xiaolong Liu, Xiaolong Zhang, Yongyi Zeng
Topics & Concepts
Photodynamic therapyHeminPhotosensitizerHyaluronic acidTumor hypoxiaCancer researchCancer cellIn vivoReactive oxygen speciesChemistryMaterials scienceBiochemistryCancerBiologyMedicineRadiation therapyGeneticsHemeBiotechnologyOrganic chemistryEnzymeInternal medicineNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesCancer, Hypoxia, and Metabolism