Reproduction and pathogenesis of short beak and dwarfish syndrome in Cherry Valley Pekin ducks infected with the rescued novel goose parvovirus
Jianye Wang, Yu Wang, Yonglin Li, Yuehua Gao, Yufeng Li, Zhiwei Jiang, Guoqiang Zhu, Xiaobo Wang
Abstract
) were induced in the surviving ducks, however, high viral loads were still detected in the duck organs, suggesting persistent NGPV infection in ducks. By incorporating the homologous Rep1 and VP1 gene from classical GPV, two chimeric viruses rJN-cVP1 and rJN-cRep1 were generated. Duck infection tests revealed that the non-structural protein Rep1 played a crucial role in the NGPV pathogenicity. The present result lays a solid foundation for further exploring how the Rep protein contributes to the NGPV pathogenesis.
Topics & Concepts
BiologyVirologyGoosePathogenesisVirusPorcine circovirusCircovirusOutbreakGeneticsImmunologyPaleontologyParvovirus B19 Infection StudiesVirus-based gene therapy researchAnimal Virus Infections Studies