Porphyromonas gingivalis Cell Wall Components Induce Programmed Death Ligand 1 (PD-L1) Expression on Human Oral Carcinoma Cells by a Receptor-Interacting Protein Kinase 2 (RIP2)-Dependent Mechanism
Sabine Groeger, Fabian Denter, Günter Lochnit, M. Lienhard Schmitz, Joerg Meyle
Abstract
), a keystone pathogen for the development of periodontitis. The bacterial cell wall component peptidoglycan uses bacterial outer membrane vesicles to be taken up by cells. Internalized peptidoglycan triggers cytosolic receptors to induce PD-L1 expression in a myeloid differentiation primary response 88 (Myd88)-independent and receptor-interacting serine/threonine-protein kinase 2 (RIP2)-dependent fashion. Interference with the kinase activity of RIP2 or mitogen-activated protein (MAP) kinases interferes with inducible PD-L1 expression.
Topics & Concepts
Porphyromonas gingivalisBiologyCell biologyKinaseProtein kinase APeptidoglycanBiochemistryCell wallGeneticsBacteriaCancer Research and TreatmentsImmune Response and InflammationOral microbiology and periodontitis research