CO₂^•– Enabled Synthesis of Phenanthridinones, Oxindoles, Isoindolinones, and Spirolactams

Abstract

We report herein that photoinduced CO 2 •– enabled reductive intramolecular radical cyclization of a variety of aryl iodide derivatives to the corresponding phenanthridinone, oxindole, isoindolinone, and spirolactam derivatives in good yields. Preliminary mechanistic studies suggested the generation of CO 2 •– through homolysis of cesium formate in the presence of light, and the further involvement of CO 2 •– and the aryl radical was directly proved by trapping with diphenyl styrene and TEMPO.

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