Antibiotic-Augmented Chemodynamic Therapy for Treatment of <i>Helicobacter pylori</i> Infection in the Dynamic Stomach Environment
Jiachang Yan, Jiayin Yu, Changxin Bu, Li Yang, Jiaoyu Chen, Xin Ding, Peiyan Yuan
Abstract
Helicobacter pylori ( H. pylori ) is one of the main causes of peptic ulcer disease and gastric cancer. The overuse of antibiotics leads to bacterial drug resistance and disruption to the gut microbiome. Herein, a nanoparticle (TA-FeHMSN@Amox) was developed, comprising amoxicillin (Amox)-loaded iron-engineered hollow mesoporous silica as the core and a metal–polyphenol shell formed by tannic acid (TA) and Fe 3+ . In acidic stomach conditions, TA-FeHMSN@Amox generates bactericidal · OH through Fenton/Fenton-like reactions of the degraded product Fe 2+ and hydrogen peroxide (H 2 O 2 ) at the infection site, achieving chemodynamic therapy (CDT). Moreover, released amoxicillin enhances therapeutic efficacy by impeding the self-repair of the bacterial cell wall damaged by CDT, overcoming the limitations of ineffective CDT under conditions lacking sufficient acidity and H 2 O 2 . The acidity-responsive CDT combined with reduced antibiotic usage ensures superior in vivo therapeutic efficacy and biocompatibility with intestinal flora, providing a highly potent strategy for treating H. pylori infections in the dynamic stomach environment.