Design, synthesis and biological evaluation of erythrina derivatives bearing a 1,2,3-triazole moiety as PARP-1 inhibitors
Shuai Li, Xinyang Li, Tingjian Zhang, Jü Zhu, Wen-han Xue, Xin-hua Qian, Fan‐hao Meng
Topics & Concepts
ChemistryPoly ADP ribose polymeraseA549 cellApoptosisMoietyMTT assayIn vitroCancer cellWestern blotBiochemistryStereochemistryEnzymePolymeraseCancerBiologyGeneGeneticsPARP inhibition in cancer therapyCalcium signaling and nucleotide metabolismCancer therapeutics and mechanisms