Direct <i>para</i>-C–H heteroarylation of anilines with quinoxalinones by metal-free cross-dehydrogenative coupling under an aerobic atmosphere
Jun Xu, Lin Huang, Lei He, Chenfeng Liang, Yani Ouyang, Jiabin Shen, Min Jiang, Wanmei Li
Abstract
This study demonstrates a metal-free cross-dehydrogenative coupling for direct para -C–H heteroarylation of anilines with quinoxalinones using air as the sole oxidant and H 2 O/DMSO as the solvent.
Topics & Concepts
MetalChemistryAtmosphere (unit)Coupling (piping)SolventCombinatorial chemistryPolymer chemistryOrganic chemistryMaterials scienceMetallurgyPhysicsThermodynamicsCatalytic C–H Functionalization MethodsSynthesis and Biological EvaluationRadical Photochemical Reactions