Multicomponent Synthesis of Biologically Relevant <i>S</i>‐Diarylmethane Dithiocarbamates Using <i>p</i>‐Quinone Methides
Sushanta Kumar Parida, Sudhir Kumar Hota, Sonal Nagarkar-Jaiswal, Priyanka Singh, Sandip Murarka
Abstract
Abstract A metal and base‐free, operationally simple, and scalable multicomponent approach towards the synthesis of S ‐diarylmethane dithiocarbamates is reported. A range of structurally and electronically diverse p ‐quinone methides are shown to react with a variety of amines, and carbon disulfide to furnish corresponding dithiocarbamates in good to excellent yields under mild conditions. Furthermore, p ‐QMs embedded with aliphatic substituents are well accommodated. Importantly, these readily accessible compounds demonstrated promising anti‐proliferative activity in the low micromolar ranges in lung adenocarcinoma cells, reiterating the importance of the developed methodology. magnified image