457MO A phase I study of ATR inhibitor M1774 in patients with solid tumours (DDRiver Solid Tumours 301): Part A1 results
T.A. Yap, A.W. Tolcher, R. Plummer, J. Mukker, M. Enderlin, Christine Hicking, Giuseppe Locatelli, Z. Szucs, Ioannis Gounaris, Johann S. de Bono
Topics & Concepts
MedicinePharmacokineticsPeripheral blood mononuclear cellInternal medicineResponse Evaluation Criteria in Solid TumorsPharmacodynamicsPARP inhibitorPharmacologyOncologyOlaparibTolerabilityGastroenterologyToxicityPhases of clinical researchIn vitroAdverse effectBiologyBiochemistryGenePolymerasePoly ADP ribose polymeraseDNA Repair MechanismsCancer therapeutics and mechanismsPARP inhibition in cancer therapy