Visible-light-promoted olefinic trifluoromethylation of enamides with CF<sub>3</sub>SO<sub>2</sub>Na
Kai Tang, Yixuan Chen, Jianping Guan, Zhujun Wang, Kai Chen, Hao‐Yue Xiang, Hua Yang
Abstract
enamides were obtained in moderate to good yields with high E-isomer selectivity under mild conditions. Preliminary mechanistic studies suggest that molecular oxygen acts as the terminal oxidant for this net oxidative process, and the E isomer selectivity could be well explained by a base-assisted deprotonation of the cation intermediate.
Topics & Concepts
ChemistryTrifluoromethylationDeprotonationReagentSelectivityMolecular oxygenBase (topology)Medicinal chemistryOxygenPhotochemistryOrganic chemistryCatalysisIonAlkylTrifluoromethylMathematicsMathematical analysisFluorine in Organic ChemistryInorganic Fluorides and Related CompoundsSulfur-Based Synthesis Techniques