Predicting genotoxicity of viral vectors for stem cell gene therapy using gene expression-based machine learning
Adrian Schwarzer, Steven R. Talbot, Anton Selich, Michael Morgan, Juliane W. Schott, Oliver Dittrich‐Breiholz, Antonella Lucía Bastone, Bettina Weigel, Teng Cheong Ha, Violetta Dziadek, Rik Gijsbers, Adrian J. Thrasher, Frank J. T. Staal, H. Bobby Gaspar, Ute Modlich, Axel Schambach, Michael Rothe
Topics & Concepts
Genetic enhancementGeneBiologyGenotoxicityGene expressionViral vectorComputational biologyStem cellVector (molecular biology)VirologyGeneticsMedicineRecombinant DNAToxicityInternal medicineVirus-based gene therapy researchViral Infectious Diseases and Gene Expression in InsectsCRISPR and Genetic Engineering