The shape anisotropy of magnetic nanoparticles: an approach to cell-type selective and enhanced internalization
Tanja Potrč, Slavko Kralj, Sebastjan Nemec, Petra Kocbek, Mateja Erdani Kreft
Abstract
. Although both shapes of nanomaterials reveal biocompatibility, we havefound significant differences in the extent of their intracellular accumulation. Contrary to spherical particles, anisotropic nanochains preferentially accumulate in cancer cells as confirmed by inductively coupled plasma (ICP) analysis, indicating that control of the nanoparticle shape geometry governs cell-type-selective intracellular uptake and accumulation.
Topics & Concepts
InternalizationAnisotropyIntracellularMaterials scienceNanoparticleMagnetic anisotropyMagnetic nanoparticlesNanotechnologyBiophysicsNuclear magnetic resonanceCondensed matter physicsCellChemical physicsChemistryMagnetic fieldMagnetizationBiochemistryPhysicsOpticsBiologyQuantum mechanicsNanoparticle-Based Drug DeliveryCharacterization and Applications of Magnetic NanoparticlesMagnetic and Electromagnetic Effects