Synthesis of Bis(3‐indolyl)methanes Mediated by Potassium <i>tert‐</i>Butoxide
A. Sofia Santos, Rita Ferro, Nuno Viduedo, Luísa B. Maia, Artur M. S. Silva, M. Manuel B. Marques
Abstract
The indole moiety is an important N-heterocycle found in natural products, and a key structural component of many value-added chemicals including pharmaceuticals. In particular, bis(3-indolyl)methanes (BIMs) are an important subgroup of indoles, composed of two indole units. Herein, we report the development of a simple method to access BIMs derivatives in yields of up to 77 % by exploiting a tBuOK-mediated coupling reaction of indoles and benzyl alcohols.
Topics & Concepts
Indole testMoietyChemistryPotassiumCombinatorial chemistryOrganic chemistrySynthesis of Indole DerivativesCatalytic C–H Functionalization MethodsRadical Photochemical Reactions