Biocompatible strategies for peptide macrocyclisation
Junming He, Pritha Ghosh, Christoph Nitsche
Abstract
peptide modifications during screening in combination with genetically encoded peptide libraries have increased the demand for peptide macrocyclisation reactions that can occur under biocompatible conditions. In this perspective, we aim to distinguish biocompatible conditions from those well-known examples that are fully bioorthogonal. We introduce key strategies for biocompatible peptide macrocyclisation and contextualise them within contemporary screening methods, providing an overview of available transformations.
Topics & Concepts
Biocompatible materialPeptideChemistryNanotechnologyMedicineMaterials scienceBiochemistryBiomedical engineeringChemical Synthesis and AnalysisClick Chemistry and ApplicationsCarbohydrate Chemistry and Synthesis