The antibacterial and antibiofilm activities of mesoporous hollow Fe<sub>3</sub>O<sub>4</sub> nanoparticles in an alternating magnetic field
Wenqin Li, Wenying Wei, Xiaopei Wu, Yanan Zhao, Honglian Dai
Abstract
. Macroscopic hyperthermia was proved not to be the sole reason for the phenomenon. Visible membrane damage was demonstrated by live/dead staining, scanning electron microscopy (SEM) and transmission electron microscopy (TEM) assays. Besides, the permeability and integrity changes of the cell membrane were then quantitatively confirmed by measuring the relative electrical conductivity. In addition, bacterial biofilms were significantly dispersed in the presence of MHFPs and AMF. These results suggested that under the mediation of AMF, MHFPs can potentially serve as an efficient nonantibiotic therapeutic platform to disperse bacterial biofilms and inactivate bacteria by damaging the cell membrane of the bacteria.