Near-infrared imaging for visualizing the synergistic relationship between autophagy and NFS1 protein during multidrug resistance using an ICT–TICT integrated platform
Wei Hu, Yifan He, Haixian Ren, Li Chai, Haiyan Li, Jianbin Chen, Chunya Li, Yanying Wang, Tony D. James
Abstract
S inducer) and autophagy during chemotherapy-induced multidrug resistance. This platform could monitor multiple endogenous metabolites and the synergistic relationship between autophagy and NFS1 protein during multidrug resistance induced by chemotherapy. The results indicated that chemotherapeutic drugs simultaneously up-regulate the levels of NFS1 protein and autophagy. It was also found that the NFS1 protein was linked with autophagy, which eventually led to multidrug resistance. As such, this platform could serve as an effective tool for the in-depth exploration of drug resistance mechanisms.
Topics & Concepts
Multiple drug resistanceAutophagyChemistryNanotechnologyNear-infrared spectroscopyInfraredMaterials scienceNeuroscienceBiologyBiochemistryPhysicsAntibioticsApoptosisOpticsAutophagy in Disease and TherapyAdenosine and Purinergic SignalingRNA Interference and Gene Delivery