Discovery of Novel Thiophene-arylamide Derivatives as DprE1 Inhibitors with Potent Antimycobacterial Activities
Pengxu Wang, Sarah M. Batt, Bin Wang, Lei Fu, Rongfei Qin, Yu Lu, Gang Li, Gurdyal S. Besra, Haihong Huang
Abstract
provides new insight into the discovery of novel antitubercular agents targeting DprE1.
Topics & Concepts
AntimycobacterialChemistryThiophenePharmacologyCombinatorial chemistryStereochemistryOrganic chemistryMycobacterium tuberculosisTuberculosisMedicinePathologyBiochemical and Molecular ResearchATP Synthase and ATPases ResearchProtein Kinase Regulation and GTPase Signaling