Current progress in cancer treatment by targeting FGFR signaling
Sicheng Du, Ying Zhang, Jianming Xu
Abstract
Fibroblast growth factor receptors (FGFRs), a family of transmembrane receptors with intracellular tyrosine kinase domains, and fibroblast growth factors (FGFs) form the FGF/FGFR signaling pathways, which participate in cell development, differentiation, cell survival, migration, angiogenesis, and
Topics & Concepts
Fibroblast growth factor receptorFibroblast growth factorAngiogenesisReceptor tyrosine kinaseTyrosine kinaseFibroblast growth factor receptor 1Cell biologySignal transductionCancer researchFibroblast growth factor receptor 3IntracellularReceptorTyrosine-kinase inhibitorBiologyCancerBiochemistryGeneticsFibroblast Growth Factor ResearchKruppel-like factors researchEpigenetics and DNA Methylation