Design, Synthesis, and Bioactivity of Novel Bifunctional Small Molecules for Alzheimer’s disease
Meihao Liang, Lili Gu, Hongjie Zhang, Jingli Min, Zunyuan Wang, Zhen Ma, Chixiao Zhang, Shenxin Zeng, Youlu Pan, Dongmei Yan, Zhengrong Shen, Wenhai Huang
Abstract
, and their effects were tested on PC12 cells. In addition, we further studied the pharmacokinetics of compound I3 in healthy rats. Our data showed that compound I3 could effectively degrade τ-protein, reduce Aβ-induced cytotoxicity, and regulate the uneven distribution of mitochondria, which may open a new therapeutic strategy for the treatment of AD.
Topics & Concepts
BifunctionalNeurotoxicityPhosphorylationCytotoxicityChemistryTau proteinAmyloid precursor proteinIn vitroAlzheimer's diseasePharmacologyCell biologyBiochemistryDiseaseMedicineBiologyPathologyToxicityCatalysisOrganic chemistryProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysClick Chemistry and Applications