<i>RB1</i> alteration and poor prognosis in women with high-grade neuroendocrine carcinoma of the uterine cervix: a NeCTuR study
Alejandra Flores Legarreta, Gloria Salvo, Naomi R. Gonzales, Gary B. Chisholm, R. Tyler Hillman, Michael Frumovitz
Abstract
OBJECTIVE: To describe the gene alteration status in high-grade neuroendocrine cervical carcinoma (NECC) specimens and to explore the potential association of unique gene alterations with survival. METHODS: Results from tumor-based molecular testing on specimens from women with high-grade NECC in the Neuroendocrine Cervical Tumor Registry were reviewed and analyzed. Tumor specimens could be from primary or metastatic sites and obtained at initial diagnosis, during treatment, or at recurrence. RESULTS: alteration (p=0.003). None of the other genes evaluated were shown to be associated with OS. CONCLUSION: alterations have decreased OS.