TNF receptor-associated factor 3 restrains B-cell receptor signaling in normal and malignant B cells
Amy L. Whillock, Tiffany K. Ybarra, Gail A. Bishop
Abstract
primary B cells was resistant to inhibition of Btk, while TRAF3-deficient malignant B-cell lines showed enhanced sensitivity. TRAF3 serves to restrain normal and malignant BCR signaling, with important implications for its role in normal B-cell biology and abnormal survival of malignant B cells.
Topics & Concepts
ReceptorCancer researchTumor necrosis factor receptorSignal transductionTumor necrosis factor alphaCell biologyChemistryEndocrinologyBiologyBiochemistryChronic Lymphocytic Leukemia ResearchImmune Cell Function and InteractionT-cell and B-cell Immunology