COL1A1-positive endothelial cells promote gastric cancer progression via the ANGPTL4-SDC4 axis driven by endothelial-to-mesenchymal transition
Quanzhong Liu, Miao Yu, Zihan Lin, Lingxiang Wu, Peng Xia, Mengyan Zhu, Bin Huang, Wei Wu, Ruohan Zhang, Kening Li, Lingjun Zhu, Qianghu Wang
Abstract
ECs in GC progression and highlight potential therapeutic targets for disrupting the EndoMT process in these cells to provide a benefit for GC patients.
Topics & Concepts
Epithelial–mesenchymal transitionCancer researchMesenchymal stem cellCancerANGPTL4Transition (genetics)MedicineBiologyInternal medicineChemistryPathologyMetastasisBiochemistryGeneLipid metabolism and disordersCancer-related molecular mechanisms researchRNA modifications and cancer