Helicobacter pylori CagA promotes immune evasion of gastric cancer by upregulating PD-L1 level in exosomes
Jinfeng Wang, Rilin Deng, Shuai Chen, Shun Deng, Qi Hu, Biaoming Xu, Junjun Li, Zhuo He, Mingjing Peng, Sanlin Lei, Tiexiang Ma, Zhuo Chen, Haizhen Zhu, Chaohui Zuo
Abstract
T cells. This study provides sights for understanding immune evasion mediated by PD-L1. Targeting CagA and exosomal PD-L1 may improve immunotherapy efficacy of Hp-infected GC.
Topics & Concepts
CagAMicrovesiclesHelicobacter pyloriImmune systemImmunotherapyCancerCancer researchExosomeImmunologyMetastasisBiologyMedicinemicroRNAInternal medicineGeneVirulenceBiochemistryHelicobacter pylori-related gastroenterology studiesGalectins and Cancer BiologyIL-33, ST2, and ILC Pathways