Molecular basis for regulation of the class I phosphoinositide 3-kinases (PI3Ks), and their targeting in human disease
Alexandria L Shaw, Isobel Barlow-Busch, John E. Burke
Topics & Concepts
Phosphoinositide 3-kinaseAllosteric regulationCell biologyBiologyRegulatorSignal transductionPI3K/AKT/mTOR pathwayChemotaxisChemistryCD74GeneComputational biologyTyrosine kinaseClass (philosophy)SignallingP110αReceptorProtein subunitReceptor tyrosine kinaseRegulation of gene expressionKinaseCell signalingPlasma protein bindingGeneticsPhosphatidylinositolJurkat cellsPI3K/AKT/mTOR signaling in cancerChronic Lymphocytic Leukemia ResearchMetabolism, Diabetes, and Cancer