Characterization of NucPNP and NucV involved in the early steps of nucleocidin biosynthesis in <i>Streptomyces calvus</i>
Utumporn Ngivprom, Surayut Kluaiphanngam, Wen-Juan Ji, Siriwalee Siriwibool, Anyanee Kamkaew, James R. Ketudat Cairns, Qi Zhang, Rung‐Yi Lai
Abstract
APRT involved in the biosynthesis of canonical purine nucleoside in the same strain. These results provide new insights in nucleocidin biosynthesis and could guide future research on organofluorine formation.
Topics & Concepts
BiosynthesisIn vitroStereochemistryStreptomycesChemistryBiologyBiochemistryGeneticsGeneBacteriaRNA and protein synthesis mechanismsRNA modifications and cancerEnzyme Structure and Function