Study on the structure-activity relationship of dihydroartemisinin derivatives: Discovery, synthesis, and biological evaluation of dihydroartemisinin-bile acid conjugates as potential anticancer agents
Xiaosu Zou, Chang Liu, Congcong Li, Rong Fu, Wei Xu, Hongzhu Bian, Xun Dong, Xiaozhen Zhao, Zhenye Xu, Jinghua Zhang, Zhengwu Shen
Topics & Concepts
DihydroartemisininChemistryIn vivoUrsodeoxycholic acidPharmacologyConjugateIC50Cell growthBiological activityStereochemistryIn vitroBiochemistryArtemisininImmunologyBiologyPlasmodium falciparumMathematicsMalariaBiotechnologyMathematical analysisHIV/AIDS drug development and treatmentQuinazolinone synthesis and applicationsDrug Transport and Resistance Mechanisms