Epidemiology of non-alcoholic fatty liver disease and hepatocellular carcinoma
Zobair M. Younossi, Linda Henry
Abstract
The prevalence of hepatocellular carcinoma (HCC) is increasing worldwide, whereas that of most other cancers is decreasing. Non-alcoholic fatty liver disease (NAFLD), which has increased with the epidemics of obesity and type 2 diabetes, increases the risk of HCC. Interestingly, NAFLD-associated HCC can develop in patients with or without cirrhosis. A lack of awareness about NAFLD-related HCC has led to delays in diagnosis. Therefore, a large number of patients with HCC are diagnosed with advanced-stage HCC with low 5-year survival. In this context, increasing awareness of NAFLD and NAFLD-related HCC may lead to earlier diagnosis and more effective interventions.
Topics & Concepts
Hepatocellular carcinomaFatty liverMedicineCirrhosisInternal medicineContext (archaeology)GastroenterologyDiseaseEpidemiologyDiabetes mellitusObesityAlcoholic liver diseaseEndocrinologyBiologyPaleontologyLiver Disease Diagnosis and TreatmentHepatocellular Carcinoma Treatment and PrognosisEndoplasmic Reticulum Stress and Disease