Building Boron Heterocycles into DNA-Encoded Libraries
Pinwen Cai, Lukas Schneider, Cedric Stress, Dennis Gillingham
Abstract
DNA-encoded library (DEL) technology uses DNA tags to track the synthetic history of individual members in a split-and-pool combinatorial synthesis scheme. DEL synthesis hinges on robust methodologies that tolerate combinatorial synthesis schemes while not destroying the information in DNA. We introduce here a DEL-compatible reaction that assembles a boron-containing pyridazine heterocycle. The heterocycle is unique because it can engage in reversible covalent interactions with alcohols─a feature that, until now, has not been deliberately engineered into DELs.
Topics & Concepts
ChemistryCombinatorial chemistryDNABoronCovalent bondComputer scienceNanotechnologyComputational biologyBiochemistryOrganic chemistryBiologyMaterials scienceChemical Synthesis and AnalysisRNA and protein synthesis mechanismsAdvanced biosensing and bioanalysis techniques