Design, synthesis, and docking studies of novel pyrazole-based scaffolds and their evaluation as VEGFR2 inhibitors in the treatment of prostate cancer
Dalia H. Soliman, Mohamed S. Nafie
Abstract
, the study revealed the potentiality of compound 3i to inhibit tumor proliferation by 49.8% reducing the tumor weight from 234.6 mg in untreated mice to 83.2 mg. Therefore, 3i could be a promising anti-prostate cancer agent.
Topics & Concepts
PyrazoleDocking (animal)Prostate cancerVEGF receptorsCombinatorial chemistryChemistryPharmacologyComputational biologyCancerMedicineCancer researchInternal medicineStereochemistryBiologyNursingAngiogenesis and VEGF in CancerEstrogen and related hormone effectsCytokine Signaling Pathways and Interactions