Palladium/Norbornene‐Catalyzed Sequential <i>ortho</i>‐Acylation and <i>ipso</i>‐Alkenylation with Carboxylic Acid: Access to Polysubstituted Aryl Ketones
Shimin Yang, Yunxia Feng, Shen Zhao, Lei Chen, Xinjin Li, Daopeng Zhang, Hui Liu, Yunhui Dong, Fenggang Sun
Abstract
Abstract Herein a palladium/norbornene‐catalyzed sequential ortho ‐acylation and ispo ‐alkenylation for access to polysubstituted aryl ketones has been developed. By exploiting dicyclohexylcarbodiimide (DCC) as activator, aryl with electron‐donating or electron‐withdrawing functionalities, alkyl, and heteroaryl carboxylic acids were compatible in this transformation, affording the desired products in decent to good yields. magnified image
Topics & Concepts
ChemistryNorborneneArylAcylationCatalysisPalladiumCarboxylic acidActivator (genetics)Organic chemistryAlkylMedicinal chemistryCopolymerBiochemistryPolymerGeneCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsSulfur-Based Synthesis Techniques