Regulation of acid-sensing ion channels by protein binding partners
Megan M. Cullinan, Robert C. Klipp, John R. Bankston
Abstract
. These proteins can impact ASIC gating, localization, cell-surface expression, and regulation. Like all ion channels, it is important to understand the cellular context under which ASICs function in neurons and other cells. Here we will review what is known about a number of these potentially important regulatory molecules.
Topics & Concepts
Acid-sensing ion channelIon channelContext (archaeology)GatingCell biologyNeurotransmissionNeuroscienceChemistryBiologyBiochemistryReceptorPaleontologyIon Transport and Channel RegulationSphingolipid Metabolism and SignalingIon channel regulation and function