Unresectable Chondrosarcomas Treated With Carbon Ion Radiotherapy: Relationship Between Dose-averaged Linear Energy Transfer and Local Recurrence
Shinnosuke Matsumoto, Sung Hyun Lee, Reiko Imai, Taku Inaniwa, Naruhiro Matsufuji, Mai Fukahori, Ryosuke Kohno, Shunsuke Yonai, Noriyuki Okonogi, Shigeru Yamada, Nobuyuki Kanematsu
Abstract
BACKGROUND/AIM: The local control rate of chondrosarcomas treated with carbon-ion radiotherapy (CIRT) worsens as tumour size increases, possibly because of the intra-tumoural linear energy transfer (LET) distribution. This study aimed to evaluate the relationship between local recurrence and intra-tumoural LET distribution in chondrosarcomas treated with CIRT. PATIENTS AND METHODS: distribution in the planning tumour volume (PTV) and local control was evaluated. RESULTS: value exceeded 40 keV/μm. CONCLUSION: may have an improved local control rate for unresectable chondrosarcomas.